Endometrial Receptivity Test

The Endometrial Receptivity Test (ERA test) is a specialized procedure used in the field of reproductive medicine to assess the condition of the endometrium, i.e., the inner layer of the uterus, and its readiness for embryo implantation. This test is especially useful for women undergoing assisted reproductive techniques such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). The ERA test is usually recommended for women with a history of unsuccessful implantation, and not as a standard procedure for all women undergoing IVF.

Why is it performed?

The ERA test is used to determine the optimal timing (the so-called “window of implantation”) when the endometrium is most favorable for embryo implantation. The test is particularly useful for women who have had several unsuccessful embryo implantation attempts despite transferring healthy embryos.

How is it performed?

The test involves taking a sample of endometrial tissue during a specific phase of the menstrual cycle, usually a few days after the expected time of ovulation or at an appropriate moment during hormonal therapy. The sample is sent to a laboratory where genetic analysis is conducted to assess the expression of certain genes related to endometrial receptivity.

Results

The results of the test show whether the endometrium was receptive at the time the sample was taken, helping to determine the best timing for embryo transfer in future IVF cycles. If the endometrium is deemed “non-receptive,” the doctor may adjust the hormonal therapy protocol to increase the chances for successful implantation. The ERA test allows for an individualized approach in assisted reproductive treatments, increasing the chances for a successful pregnancy.